1964 Gordon Research Conference on Nucleic Acids

Cytologic and Cytotoxic Changes Induced by Nucleic Acids.

Nucleic acids and protein prepared from Sarcoma 180, from Ehrlich ascites tumor, from NCTC 929 cells derived from strain L, and from normal mouse liver, when injected subcutaneously in mice with cultured viable NCTC 929 strain L cells, oc casionally induce cytologie atypia in the NCTC 929 cells, characterized by giant cells, abnormal cytoplasmic shapes and staining, large nuclei, and prominence...

Turnover of nucleic acids in a multiplying animal cell. 2. Retention studies.

Effect of Orotic Acid on the Metastasis of Mammary Tumors in Mice.

In the course of studying the effect of nucleic acid precursors on viral carcinogenesis it was observed that an increased number of métastasesdeveloped in the lungs of orotic acid-treated mice with spontaneous mammary tumors. Further evidence that orotic acid increases the establishment of lung métastaseswas noted when orotic acidtreated C3H/HeN mice given injections intravenously of a cell s...

Effect of Hydroxyurea on Pseudomonas Aeruginosa.

Hydroxyurea was shown to inhibit the growth of species of Pseudomonas. The growth of fungi, yeasts, and other bacteria was unaffected. Inhibition of the growth of Ps. aeruginosa was accompanied by marked elongation of individual cells. Electron microscopy revealed that nuclear material of inhibited cells was either virtually absent or coalesced into electron-dense particles. Chemical analyses s...

Handbook of Basic Microtechnique

spectra proteins, nucleic acids, and viruses. A particularly good presentation is given of our present theoretical understanding of hyperchromicity of DNA. The action of ultraviolet light on amino acids, proteins, purine and pyrimidine derivatives, oligonucleotides, and nucleic acids are presented in depth and clarity in individual chapters. The presentation of what is known about the photochem...